Table 2.
Effect of Antibiotic Treatment
| Mice | Inflammation | No lesion | Hyperplasia | Dysplasia | Carcinoma |
|---|---|---|---|---|---|
| Stat3-IKO (8–27 weeks) | 14/15 (93%) | 5/15 (33%) | 10/15 (67%) | 10/15 (67%) | 3/15 (20%) |
| Stat3-IKO VNMA-treated (21–27 weeks) | 3/11 (27%) | 9/11 (82%) | 2/11 (18%) | 0 | 0 |
| Stat3f/f (8–27 weeks) | 1/16 (6%) | 16/16 (100%) | 0 | 0 | 0 |
Statistic analysis: Fisher’s exact test, two-tailed for inflammation: Stat3-IKO VNMA treated versus untreated, P < 0.001; Stat3 IKO VNMA treated versus Stat3f/f untreated, P = 0.55; for tumor development (dysplasia): Stat3-IKO VNMA treated versus untreated, P < 0.001; for tumor development (carcinoma): Stat3-IKO VNMA-treated versus untreated, P = 0.175.