Figure 3.

Histology of the mammary grafts from Hoxa5/p53 allelic combinations that did not develop tumors. H&E stained sections of representative mammary glands are shown. A: Control mammary graft displayed large adipocytes and ducts surrounded by a thin stroma. In B and D, no obvious alterations were detected in Hoxa5^+/−/p53^+/+ (B) and Hoxa5^+/+/p53^+/− (D) grafts. C: Precocious lobuloalveolar development and epithelial hyperplasia were observed in Hoxa5^−/−/p53^+/+ specimens as previously shown in Hoxa5^−/− females.28 E: Adipocytes with microvesicular fat droplets (arrows) and intense reactive stroma were often seen in Hoxa5^+/−/p53^+/− grafts. Scale bar = 100 μm.