Table 3.

Clinical and Genetic Features of 143 Patients with HCC Due to Mixed Causes According to the MDM2 −309 Genotype

	−309 MDM2
	T/T	T/G	G/G
n	50	70	23
MDM2 activity	+	++	+++
P53 activity	+++	++	+
Age, years	66.1 ± 9	64.5 ± 8	65.1 ± 8
Sex, M	38 (76)	51 (73)	19 (83)
Alcohol abuse*	16 (32)	15 (21)	12 (52)
HCV and / or HBV	32 (64)	52 (74)	17 (74)
HFE mutations**	9 (18)	20 (28)	10 (43)

^*P = 0.02; 

^**P = 0.05; (): % values.