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. 2009 Oct 14;115(2):161–167. doi: 10.1182/blood-2009-03-210179

Figure 2.

Figure 2

The proportion of monocytes expressing TF and plasma levels of bioactive TF are increased in HIV infection, and monocyte TF correlates with markers of immune activation. Whole-blood samples obtained from 60 HIV-infected donors and 19 healthy controls were examined for expression of TF on gated CD14+ monocytes and for markers of immune activation (HLA-DR and CD38) on gated CD8+ T cells by flow cytometry. (A) Representative histograms and dot plots. (B) Summary data among healthy controls, patients with controlled (HIV RNA < 400 copies/mL), and uncontrolled (HIV RNA > 400 copies/mL) viremia. (C) Bioactive TF was significantly higher in plasma samples from HIV-infected patients (n = 28) than in samples from uninfected controls (n = 8, P < .001). (D) Correlation between the proportion of TF+ monocytes and the proportion of CD8+ T cells that express activation markers (r = 0.61, P < .001).