Plasma levels of the LPS coreceptor, CD14, are increased in HIV infection and correlate with the proportion of TF+ monocytes in patients with detectable viremia. Plasma was collected from whole-blood samples provided by HIV-infected (N = 46) and -uninfected donors (N = 18), and levels of sCD14 were measured. (A) sCD14 levels are higher in plasmas of HIV+ patients than in plasmas of healthy controls (P < .005). (B) Plasma levels of sCD14 correlate with the proportion of TF+ monocytes among all subjects (r = 0.51, P < .001). (C) Plasma levels of sCD14 correlate with the proportion of TF+ monocytes among patients with detectable viremia (r = 0.44, P = .042, n = 22).