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Study design. The patients in the on-treatment group were given either 180 μg of peginterferon-alpha 2a subcutaneously 24 hours prior to liver biopsy or 1000/1200 mg of ribavirin daily for 72 hours plus 180 μg of peginterferon-alpha 2a subcutaneously 24 hours prior to liver biopsy. After the biopsy, the patients were continued on the therapy for 48 weeks.
