Table 2.

Selected Genes Induced by Peginterferon Treatment with a Fold Change Greater Than or Equal to 1.5 (P ≤ 0.01)

Gene Category	Gene Name	Gene Symbol	Fold Change (On-Treatment/Pretreatment)	P
ISG	2′,5′-Oligoadenylate synthetase 3	OAS3	2.2	0.0001
	Adenosine deaminase, RNA-specific	ADAR	1.5	2.6 × 10−7
	Guanylate binding protein 1	GBP1	2.3	9.2 × 10−6
	IFN transmembrane protein 1 (9–27)	IFITM1	1.7	0.0009
	IFN-alpha–inducible (ISG 15)	ISG15	1.8	0.001
	IFN-induced protein 35	IFI35	1.7	0.0001
	IFN-induced protein 44	IFI44	2.4	3.8 × 10−5
	IFN-induced protein with TTPR 3	IFIT3	1.7	0.004
	IFN-induced protein with TTPR 5	IFIT5	1.5	3.1 × 10−5
	Myxovirus resistance 1	Mx1	2.3	9.2 × 10−6
	Myxovirus resistance 2	Mx2	2.5	5.9 × 10−7
	Phospholipid scramblase 1	PLSCR1	3.0	4.6 × 10−8
	Ubiquitin specific protease 18	USP18	1.8	0.0009
	Viperin	RSAD2	2.3	5.3 × 10−5
	Apolipoprotein B messenger RNA editing enzyme catalytic polypeptide-3A	APOBEC3A	3.8	6.9 × 10−8
IFN-related	IFN-alpha/beta receptor 2	IFNAR2	1.7	0.0001
	IFN regulatory factor 7	IRF7	2.5	6.0 × 10−5
	RIG-I DEAD box polypeptide 58	DDX58	1.6	0.0018
	Signal transducer/activator transcription	STAT1	2.3	1.2 × 10−6
Immune	Beta-2-microglobulin	B2M	2.3	3.2 × 10−5
	Chemokine ligand 8	CCL8	4.6	1.16 × 10−8
	Chemokine ligand 19	CCL19	2.6	0.005
	C-reactive protein	CRP	4.0	0.0032
	Interleukin 18 binding protein	IL18BP	1.8	2.6 × 10−5
	Interleukin 6 signal transducer	IL6ST	2.3	7.5 × 10−6
	Major histocompatibility complex F	HLA-F	1.5	0.0002
	N-myc and STAT interactor	NMI	1.7	2.8 × 10−6
	Nuclear factor of activated T cells	NFAT5	1.6	0.0002
	Serum amyloid A1	SAA1	10.5	7.0 × 10−5

Abbreviations: IFN, interferon; ISG, interferon-stimulated gene.