Table 5.

Comparison of a Surrogate for the Fold Induction of Selected Genes Differing Between RRs and SRs with a Fold Change Greater Than or Equal to 1.5 (P ≤ 0.01) in the On-Treatment Group Versus the Pretreatment Group (On-Treatment RRs/Pretreatment RRs versus On-Treatment SRs/Pretreatment SRs)

			RRs (On-Treatment/Pretreatment)		SRs (On-Treatment/Pretreatment)
Gene Category	Gene Name	Gene Symbol	Fold Change	P	Fold Change	P
ISG	2′,5′-Oligoadenylate synthetase 1	OAS1	6.7	0.0004	1.0	NS
	2′,5′-Oligoadenylate synthetase 2	OAS2	16.5	2.9 × 10−5	1.2	NS
	2′,5′-Oligoadenylate synthetase 3	OAS3	8.8	0.0005	1.2	NS
	28-kD IFN-responsive protein	IFRG28	3.5	0.0003	NC	NS
	Adenosine deaminase, RNA-specific	ADAR	1.8	1.5 × 10−6	NC	NS
	Guanylate binding protein 1	GBP1	2.5	0.0003	NC	NS
	IFN-induced transmembrane protein 1 (9–27)	IFITM1	5.4	0.0063	1.1	NS
	IFN-induced transmembrane protein 2	IFITM2	1.7	0.0004	NC	NS
	IFN-induced with helicase C domain	IFIH1	3.4	1.3 × 10−5	NC	NS
	IFN-stimulated exonuclease gene 20Kda	ISG20	4.6	0.0014	NC	NS
	IFN-induced protein 35	IFI35	4.6	0.0002	1.1	NS
	IFN-induced 44-like	IFI44L	57.9	0.0066	1.3	NS
	IFN-induced protein with TTPR 1	IFIT1	6.0	0.0003	NC	NS
	IFN-induced protein with TTPR 2	IFIT2	5.9	0.0022	NC	NS
	IFN-induced protein with TTPR 3	IFIT3	5.8	0.0005	1.1	NS
	IFN-induced protein with TTPR 5	IFIT5	3.0	0.0001	1.1	NS
	IFN-stimulated gene 15	ISG15	13.6	0.005	1.6	0.014*
	Myxovirus resistance 1	Mx1	17.7	0.006	1.1	NS
	Myxovirus resistance 2	Mx2	5.7	2.7 × 10−5	1.6	NS
	Viperin	RSAD2	12.1	0.0007	1.9	1.1 × 10−5
IFN-related	IFN-alpha 4	IFNA4	3.4	0.0070	NC	NS
	IFN receptor	IFNAR2	NC	NS	2.4	0.0011
	IFN regulatory factor 7	IRF7	3.3	0.0040	1.2	NS
	IFN-stimulated transcription factor	ISGF3G	2.0	1.5 × 10−6	NC	NS
	RIG-I DEAD box polypeptide 58	DDX58	2.7	5.8 × 10−7	NC	NS
	Signal transducer activator of transcription 1	STAT1	5.2	0.0001	1.8	0.003
IFN-inhibitory	Protein inhibitor of activated STAT 2	PIAS2	NC	NS	1.1*	0.00001
	Protein inhibitor of activated STAT 4	PIAS4	NC	NS	1.2*	5.4 × 10−5
	Protein phosphatase 2 regulatory subunit B	PPP2R2C	NC	NS	3.5	0.0002
	gamma (formerly 2A)
	Protein phosphatase 2 regulatory subunit B	PPP2R3A	NC	NS	6.6	0.0001
	alpha (formerly 2A)
	Small ubiquitin-like molecule 1	SUMO1	−1.6	0.006	NC	NS
	Ubiquitin-specific peptidase 13	USP13	NC	NS	2.3	0.0002
	Ubiquitin-specific peptidase 18	USP18	5.33	2.5 × 10−6	NC	NS
Immune	Chemokine (C-X-C motif) receptor 1	CCR1	2.0	0.0023	NC	NS
	Chemokine (C-C motif) ligand 14	CCL14	−1.6	0.0002	−2.8	0.0001
	Chemokine (C-X-C motif) ligand 11	CXCL11	5.4	0.0008	NC	NS
	Complement component 1 subunit s1	C1S	−7.1	3.9 × 10−6	NC	NS
	Complement component 2	C2	−2.0	0.0041	NC	NS
	Complement component 9	C9	1.5	0.0013	NC	NS
	Interleukin 6 receptor	IL6R	−6.4	9.0 × 10−7	NC	NS
	Interleukin 13 receptor alpha 1	IL13RA1	−2.0	3.9 × 10−5	−1.1	NS
	Interleukin 17 receptor B	IL17RB	−2.1	0.0007	−2.1	2.7 × 10−6
	Interleukin 18 binding protein	IL18BP	2.7	2.8 × 10−5	NC	NS
Other	Insulin receptor	INSR	−2.0	2.4 × 10−5	NC	NS
	Insulin-like growth factor 2	IGF2	−1.7	1.3 × 10−5	NC	NS
	Integrin beta 1	ITGB1	−2.3	2.7 × 10−7	NC	NS
	Leptin receptor	LEPR	−3.8	4.1 × 10−6	−1.3	NS

^*P between 0.05 and 0.01 or a fold change between 1.0 and 1.5. Abbreviations: IFN, interferon; ISG, interferon-stimulated gene; NC, no change in the gene expression detected between groups; NS, not statistically significant; RR, rapid responder; SR, slow responder.