Table 3.
List of some enriched GO annotations.
| Regulators | Functional description of regulators | # of genes | Significantly shared GO annotations | P value |
|---|---|---|---|---|
| RAP1 | High level transcriptional activation of genes encoding ribosomal proteins and glycolytic enzymes | 126 | (86/126) structural constituent of ribosome | 2.66E–100 |
| (91/126) translation | 8.79E–83 | |||
| SUM1 | Mitotic repression of middle sporulation-specific genes, general replication initiation | 45 | (16/45) sporulation | 9.93E–15 |
| LEU3 | Regulates the transcription of genes encoding enzymes involved in branched-chain amino acid synthesis | 10 | (6/10) branched chain family amino acid biosynthetic process | 1.45E-13 |
| UME6 | Transcriptional regulator of early meiotic genes, transcriptional regulation of genes involved in arginine catabolism | 44 | (2/43) arginine catabolic process | 0.00571 |
| (7/43) meiosis | 0.00797 | |||
| TEC1 | Required for full Ty1 expression, Ty1-mediated gene activation | 20 | (17/20) transposition, RNA-mediated | 3.85E-25 |
| ARG81 | Involved in the regulation of arginine-responsive genes | 9 | (6/9) arginine metabolic process | 2.78E-13 |
| SFP1 | Controls expression of many ribosome biogenesis genes in response to nutrients and stress, regulates G2/M transitions during mitotic cell cycle and DNA-damage response | 66 | (42/66) structural constituent of ribosome | 8.62E-45 |
| (46/66) translation | 2.90E-39 | |||
| RFX1 | Involved in DNA damage and replication checkpoint pathway | 6 | (3/6) deoxyribonucleotide biosynthetic process | 2.18E-07 |
| GCR1 | Transcriptional activators of glycolytic genes | 50 | (10/50) glycolysis | 5.94E-14 |
| BAS1 | Involved in the expression of genes encoding enzymes acting in the histidine, purine, and pyrimidine biosynthetic pathways | 12 | (4/12) purine ribonucleoside monophosphate biosynthetic process | 1.28E-07 |
| ARG80 | Involved in regulation of arginine-responsive genes | 5 | (4/5) arginine biosynthetic process | 7.63E-10 |
| DIG1 | Involved in the regulation of mating-specific genes, inhibits pheromone-responsive transcription | 13 | (8/13) sexual reproduction | 1.89E-09 |
| (8/13) response to pheromone | 2.93E-10 | |||
| HMS1 | Overexpression confers hyperfilamentous growth | 23 | (15/23) cytosolic part | 1.02E-15 |
| ACE2 | Activates transcription of genes expressed in the G1 phase | 12 | (4/12) cytokinesis, completion of separation | 8.06E-08 |
| YAP1 | Activates the transcription of anti-oxidant genes in response to oxidative stress | 8 | (4/8) response to oxidative stress | 5.32E-05 |
| OPI1 | Negative regulation of phospholipid biosynthetic genes | 3 | (2/3) fatty acid synthase complex | 2.54E-06 |
| SKO1 | Cytosolic and nuclear protein involved in osmotic and oxidative stress responses | 9 | (2/9) structural constituent of cell wall | 0.00094 |
| TYE7 | transcriptional activator in Ty1-mediated gene expression, binds E-boxes of glycolytic genes and contributes to their activation | 24 | (9/24) transposition, RNA-mediated | 7.74E-08 |
| (4/24) glycolysis | 9.21E-05 | |||
| GAL80 | involved in transcriptional regulation in response to galactose | 6 | (4/6) galactose metabolic process | 1.86E-09 |
| GCR2 | transcriptional activators of glycolytic genes | 6 | (6/6) glycolysis | 5.08E-14 |
| SUT1 | involved in sterol uptake; involved in induction of hypoxic gene expression | 13 | (3/13) structural constituent of cell wall | 1.37E-05 |
| INO2 | required for derepression of phospholipid biosynthetic genes in response to inositol depletion | 5 | (4/5) lipid biosynthetic process | 2.77E-05 |
Functional description of regulators is from the Saccharomyces Genome Database.
Gene Ontology analysis done using GO Term Finder in SGD in Aug 31, 2008; 5952 genes were included in the background set with P-value cut-off < 0.01.