Table 3. rhIL-7 pharmacokinetics.
Upper panel: mean serum concentrations for cohorts Lower panel: Pharmacokinetics parameters (mean values for a cohort). Results are shown after the first dose (d1) and after the last dose (d14) for each cohort.
| Dose | 10μg/Kg | 30μg/Kg | 60μg/Kg | |||
|---|---|---|---|---|---|---|
| rhIL-7 serum levels (pg/ml) | ||||||
| Time (hrs) | d 1 | d 14 | d1 | d 14 | d 1 | d 14 |
| 0 | 6 | 0 | 0 | 10 | 0 | 0 |
| .5 | 51 | 35 | 506 | 372 | 534 | 929 |
| 1 | 93 | 48 | 837 | 399 | 908 | 1019 |
| 1.5 | 121 | 57 | 1335 | 616 | 1279 | 1324 |
| 2 | 148 | 66 | 1895 | 688 | 1246 | 1354 |
| 2.5 | 147 | 69 | 1766 | 426 | 1223 | 1344 |
| 4 | 354 | 83 | 1531 | 717 | 1176 | 1211 |
| 8 | 120 | 53 | 917 | 459 | 821 | 177 |
| 12 | 87 | 58 | 936 | 438 | 832 | 161 |
| 24 | 28 | 6 | 296 | 122 | 478 | 139 |
| Pharmacokinetics parameters | ||||||
|
Mean total daily dose (μg) |
686 | 686 | 2322 | 2322 | 4763 | 5280 |
| Cmax (pg/ml) | 354 | 83 | 1895 | 717 | 1846 | 1697 |
| Tmax (h) | 4.0 | 4.0 | 2.0 | 4.0 | 4.0 | 4.0 |
|
AUC total (pg/ml*min) |
168357 | 69697 | 1416470 | 591776 | 1812870 | 1483180 |
| t ½ (h) | 8.54 | 9.80 | 9.03 | 6.46 | 8.92 | 7.23 |
|
Clearance (ml/min) |
4077 | 9847 | 1639 | 3890 | 2627 | 3560 |