Fig. 1.

(A) Measurement schematics. (Top) Overview of a NWFET array fabricated on a transparent substrate with slice oriented with pyramidal cell layer over the devices. (Bottom Left) Zoom-in of device region illustrating interconnected neurons and NWFETs. (Bottom Right) Photograph of the assembled sample chamber. 1, 2, and 3 indicate the mitral cells in the olfactory bulb, the lateral olfactory tract, and the pyramidal cells, resp. 4 and 5 mark the stimulation electrode and the patch clamp pipette, resp. (B) Top view of the NWFET array/brain slice region in fully assembled chamber with medium. Red Box shows a higher resolution image of a single device in contact with the neurons at the bottom of the slice. Blue Box shows the outermost neurons of the slice through an immersed lens from the top. Scale bars are 20 μm. (C) Laminar organization and input circuitry of the piriform cortex (Layer I–III). (D) Conductance recording from a NWFET (Lower Traces) in the same region as neuron used to record cell-attached patch clamp results (Upper Traces). Stimulation in the LOT was performed with strong (200 μA, Red Traces) and weak (50 μA, Blue Traces) 200 μs current pulses. The Open Triangle marks the stimulation pulse.