Table 5. Generalized linear model of indels.
Polymorphic human | Fixed human | Chimp | ||||
p-value<10−206 | p-value<10−44 | p-value<10−91 | ||||
Effect | p-value | Effect | p-value | Effect | p-value | |
Ln(recombination) | ||||||
AT→GC SNPs | + | 2.5×10−5 *** | ||||
Othera SNPs | + | 9.8×10−15 *** | ||||
AT→GC fixed hum | + | 8.2×10−10 *** | ||||
Othera fixed hum | + | 0.0097 ** | + | 1.0×10−10 *** | + | 0.0035 ** |
AT→GC chimp | + | 4.1×10−4 *** | ||||
Othera chimp | + | 0.079 . | + | <10−15 *** | ||
GC | − | 2.2×10−5 *** | − | 0.0058 ** | ||
polyAT | + | 9.6×10−4 *** | + | 1.3×10−6 *** | + | 0.015* |
CpG | + | 0.05 * | ||||
%CDS | − | <10−15 *** | − | 5.9×10−12 *** | − | 1.8×10−12 *** |
%UTR | + | 0.0083 ** | + | 0.042 * | ||
SINE | − | 1.9×10−9 *** | − | 0.017 * | − | 0.0013 ** |
LINE | ||||||
Repeat maskedb | ||||||
Chromosome X | − | 9.1×10−11 *** | ||||
Telomere distance | − | 0.0074** | ||||
Not scanned | ||||||
ID | − | 2.4×10−9 *** | − | 1.6×10−4 *** | ||
ID : Ln(recombination) | + | 0.096 . | ||||
ID : AT→GC SNPs | ||||||
ID : Othera SNPs | ||||||
ID : AT→GC fixed hum | − | 0.064 . | ||||
ID : Othera fixed hum | ||||||
ID : AT→GC chimp | ||||||
ID : Othera chimp | ||||||
ID : GC | + | 8.4×10−4 *** | + | 2.1×10−4 *** | ||
ID : polyAT | + | 7.8×10−4 *** | + | 0.0023 ** | ||
ID : CpG | ||||||
ID : %CDS | ||||||
ID : %UTR | ||||||
ID : SINE | ||||||
ID : LINE | ||||||
ID : Repeat maskedb | ||||||
ID : Chromosome X | ||||||
ID : Telomere distance | − | 0.027 * | ||||
ID : Not scanned |
single nucleotide changes not AT→GC.
not due to SINEs or LINEs
Summary of the variables affecting the number of indels in the data. Significance of explanatory variables in generalized linear models for counts of indels are reported. The effect is only reported as decreasing or increasing number of insertions (deletions). An empty box indicates nonsignificance. “ID” indicates whether deletions or insertions are predicted. See text for interpretation of the positive effect of the “ID:GC” and “ID:poly AT” terms.