Figure 1. Histological and immunohistochemical features.

A and B. The cerebral cortex is markedly disrupted with prominent astrogliosis and presence of amyloid plaques (arrows in B); frontal cortex; H.E. C and D: PrP immunostaining shows the presence of many plaques (arrows) and plaque-like aggregates in superficial and deep cortical regions with a punctate background staining; frontal cortex. E: Distinctive spot-like PrP immunostaining in the molecular layer and many plaques especially evident in the Purkinje cell layer of the cerebellum. F: Plaques, often in a row are present in the superficial white matter; cerebellum. C–F: Monoclonal antibody (mAb) 3F4.