Table 1. Body composition, energy intake and OGTT results after 30 weeks.

	Control	Western	Low CHO	Moderate CHO
Body weight (grams)	590±9	676±5 ***	651±14	633±9 ###
Fat mass (g)	83±6	192±6 ***	189±7	150±6 ### †††
Lean mass (g)	456±5	445±5	425±8	441±7
Delta weight (22–30 wks) (g)	11±4	25±3 **	15±5	−25±6 ### †††
Delta fat mass (22–30 wks) (g)	−3±2	19±2 ***	21±3	−21±5 ### †††
Delta lean mass (22–30 wks) (g)	8±3	1±2	−8±3 #	−9±3 #
Energy intakes (22–30 wks) (kcal/day)	68±1	73±1 ***	83±2 ###	69±1 # †††
Fasting glucose (mmol/l)	6.4±0.2	7.2±0.2 **	6.8±0.1 #	7.3±0.2†
Fasting insulin (mU/l)	48±10	75±8 **	51±6 #	48±3 ##
OGTT Glucose AUC (mU/l per 2 h)	960±17	1189±29 ***	1120±41	1163±48
OGTT Insulin AUC (mU/l per 2 h)	12173±2071	16443±1976	13070±1309	11359±1124 #

Data presented as mean ± SEM for lean controls (n = 11), and diet-induced obese rats after 8 weeks on Western (n = 12), low carbohydrate (low CHO) (n = 12), and moderate carbohydrate (moderate CHO) diets (n = 12). Comparisons were made either between control and Western diets or between Western, low CHO and moderate CHO diets by one way ANOVA with post-hoc testing using Fisher's least significant differences test. ** p<0.01, *** p<0.001 Western vs control diet; ^# p<0.05, ^## p<0.01, ^### p<0.001 versus Western diet; ^† p<0.05, ^††† p<0.001 vs low CHO diet. AUC = area under curve. OGTT = oral glucose tolerance test.

Footnote: The difference between body weight and the sum of lean and fat tissue was attributed to skeletal mass and gut contents, both of which gave a low MRI signal.