Table 1.
Parameter differences between circuits of group 1 and circuits of group 2-3.
| parameter differences between circuits of group 1 and group 2-3 | ||||
|---|---|---|---|---|
| θ | m1 | m2 | dm | p - value |
| tll → cad | -0.0171377 | -0.02491 | -0.00777229 | 1.04553e - 010 |
| hb → hb | 0.0217064 | 0.015097 | -0.00660943 | 1.34364e - 011 |
| gt → hb | 0.0122061 | -0.00414659 | -0.0163527 | 0 |
| kni → hb | -0.128935 | -0.0747608 | 0.0541739 | 5.28773e - 009 |
| Kr → Kr | 0.0161343 | 0.0227917 | 0.00665739 | 4.79087e - 007 |
| gt → Kr | -0.0528814 | -0.027446 | 0.0254355 | 2.71076e - 010 |
| hb → gt | -0.003434 | 0.00397726 | 0.00741126 | 8.47311e - 011 |
| gt → gt | 0.0132754 | 0.0164244 | 0.00314898 | 2.4076e - 006 |
| tll → gt | -0.0155584 | -0.0438868 | -0.0283284 | 1.11022e - 015 |
| gt → tll | -0.0252096 | -0.00316618 | 0.0220435 | 3.74904e - 007 |
| m → Kr | 0.0525071 | 0.0306038 | -0.0219033 | 6.33614e - 007 |
| m → gt | 0.0703723 | 0.0261228 | -0.0442495 | 8.70947e - 009 |
T-test comparison of circuit parameters belonging to a group with a normal pattern without any defection (group 1) and a solution for which hb has a dip and tll a bump (group 2 and 3).
In groups 2 and 3, Gt represses hb, causing the dip observed at anterior hb. Also, Hb activates gt (contrarily to group 1). Consequently, there should be an increased production of anterior gt and something should locally repress gt to keep it at its normal level. At this position, Tll is the gene that controls gt expression level, and one way to keep it constant would be to increase the repression weight.