Table 3.

Cause-specific hazard ratio (HR) models^*

Characteristics of individuals	Pancreatic cancer, HR† (95% CI)	P	Death from other causes, HR (95% CI)	P
Familial
Youngest age of onset in relative (per year younger)	1.55 (1.19 to 2.03)	.001	1.09 (0.90 to 1.32)	.38
Three or more first-degree relatives	2.95 (1.24 to 7.04)	.015	—
Ever-smoker	—		1.47 (0.96 to 2.25)	.075
Unknown smoking history	—		1.09 (0.64 to 1.87)	.076
Male	—		1.36 (0.97 to 1.92)	.079
Sporadic
Youngest age of onset	0.99 (0.59 to 1.66)	.99	0.95 (0.80 to 1.14)	.61
Ever-smoker, age <70 y	—		3.22 (1.22 to 8.54)	.019
Ever-smoker, age >70 y	—		1.05 (0.66 to 1.68)	.83
Unknown smoking history, age <70 y	—		6.32 (1.30 to 30.70)	.02
Unknown smoking history, age >70 y	—		1.54 (0.91 to 2.61)	.11
Male, age <70 y	—		0.93 (0.46 to 1.88)	.83
Male, age >70 y	—		1.69 (1.14 to 2.50)	.01

^*The HRs were estimated from a Cox proportional hazards model in which the competing event is treated as censored. These models cannot be interpreted in the same manner as a standard proportional hazards model without a competing event (see text). CI = confidence interval.

^†The inferences regarding youngest age of onset were not changed by including smoking status and sex. Therefore, the reduced model is presented as the bootstrap estimates for cumulative incidence are based on these models.