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. 2009 Nov 19;29(1):251–262. doi: 10.1038/emboj.2009.333

Figure 3.

Figure 3

Crystal structures of hPrP mutants. (A) Packing between two D178N/M129 dimers. An intermolecular antiparallel, four-stranded β-sheet (orange) containing M129 (space-filling spheres) is formed at the dimer:dimer interface; the variant N178 side chains are also shown. (B) A close-up view of the D178N/M129 intermolecular β-sheet containing M129. (C) D178N/V129 dimers do not pack to form intermolecular β-sheets; instead these dimers are rotated ∼90 degrees with respect to each other. (D) A close-up view of the D178N/V129 β-sheets. The V129 side chains do not approach each other and the β-sheets do not interact. (E) F198S/V129 dimers form an intermolecular β-sheet. While the F198S/M129 dimer:dimer interaction (Supplementary Figure S1C) is nearly identical to that for D178N/M129, the F198S/V129 is slightly twisted in comparison. (F) A close-up view of the F198S/V129 intermolecular β-sheet. The disordered/flexible hinge loop residues are represented by dashed lines.