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. Author manuscript; available in PMC: 2010 Nov 24.
Published in final edited form as: J Am Coll Cardiol. 2009 Nov 24;54(22):2052–2062. doi: 10.1016/j.jacc.2009.08.028

Figure 1. Diagramatic location of 162 different mutations in the KCNH2 potassium channel involving 858 subjects.

Figure 1

The α subunit involves the N-terminus (NH3+), six membrane-spanning segments, and the C-terminus portion (COO-). The numbers in the parentheses refer to the position of the amino acid beginning at the N-term position (1), the beginning of the transmembrane non-pore S1-S4 sequence (398), the beginning of the transmembrane S5-loop-S6 sequence (552), the end of the transmembrane S6 sequence (657), and at the C-term end position (1159). The open circles represent individual amino acids, the red circles indicate the missense mutations, and the blue circles indicate non-missense mutations. The cylinders represent putative α-helical segments, and the bars represent putative β-sheets.