Figure 2. Kaplan-Meier estimate of the cumulative probability of a first cardiac event by type.
(A), location (B), and topology (C) of the mutation for all 858 subjects with genetically confirmed KCNH2 mutations. Kaplan-Meier estimate of the cumulative probability of a first cardiac event for missense mutations within different locations (D) and for mutations located in the α-helical domains within different locations (E). The numbers in parentheses reflect the cumulative event rate at that point in time.