Table 2.
Induction of globin gene activity by HDAC inhibitors
| Compound | Compound concentration in GM979 cell cultures, μM | Change in γF/γF + γR luciferase ratio | Compound concentration in BFUe cultures, μM | Fold increase in γ/γ + β mRNA ratio |
|---|---|---|---|---|
| M344 | 5 | 5.91 | 1.25 | 3.74 |
| M360 | 5 | 2.31 | — | — |
| M355 | 20 | 0.83 | — | — |
| MD85 | 10 | 0.68 | — | — |
| SW68 | 24 | 5.41 | 5 | 5.43 |
| SW70 | 24 | 6.00 | 5 | 3.27 |
| SW99 | 50 | 2.85 | 5 | 3.67 |
| SW86 | 10 | 1.69 | 5 | 1.81 |
| M232 | 10 | 2.53 | 6 | 2.34 |
| SW183 | 4 | 0.56 | — | — |
| SW187 | 4 | 0.39 | — | — |
| SW188 | 4 | 1.08 | — | — |
| SW189 | 4 | 0.89 | — | — |
| HR13 | 2 | 2.60 | 5 | 3.27 |
| HR10 | 10 | 1.00 | — | — |
| HR11 | 10 | 1.65 | 10 | 1.52 |
| Butyrate | 2000 | 5.32 | 200 | 3.54 |
| 4-Phenylbutyrate | 2000 | 2.95 | 500 | 3.08 |
| Isobutyramide | 5000 | 1.30 | 2000 | 1.52 |
— indicates not done.