Table 1.
A subset of malignancy-risk genes associated with cancer relapse/progression and metastasis*.
| Affy probe set id | Gene Symbol | Turashvili et al | Chanrion et al | Ma et al | van ‘t Veer et al | Wang et al | Huang et al | Gene Title |
|---|---|---|---|---|---|---|---|---|
| 222608_s_at | ANLN | Y | Y | Y | anillin, actin binding protein (scraps homolog, Drosophila) | |||
| 202095_s_at | BIRC5 | Y | Y | Y | Y | baculoviral IAP repeat-containing 5 (survivin) | ||
| 209642_at | BUB1 | Y | Y | Y | Y | Y | BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast) | |
| 203755_at | BUB1B | Y | Y | Y | Y | BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast) | ||
| 214710_s_at | CCNB1 | Y | Y | Y | cyclin B1 | |||
| 202705_at | CCNB2 | Y | Y | Y | Y | Y | cyclin B2 | |
| 205034_at | CCNE2 | Y | Y | Y | Y | cyclin E2 | ||
| 203213_at | CDC2 | Y | Y | Y | Y | Cell division cycle 2, G1 to S and G2 to M | ||
| 203214_x_at | CDC2 | Y | Y | Y | Y | cell division cycle 2, G1 to S and G2 to M | ||
| 210559_s_at | CDC2 | Y | Y | Y | Y | cell division cycle 2, G1 to S and G2 to M | ||
| 1555758_a_at | CDKN3 | Y | Y | Y | Y | Y | cyclin-dependent kinase inhibitor 3 (CDK2-associated dual specificity phosphatase) | |
| 209714_s_at | CDKN3 | Y | Y | Y | Y | Y | cyclin-dependent kinase inhibitor 3 (CDK2-associated dual specificity phosphatase) | |
| 204962_s_at | CENPA | Y | Y | Y | Y | Y | centromere protein A, 17kDa | |
| 207828_s_at | CENPF | Y | Y | Y | Y | centromere protein F, 350/400ka (mitosin) | ||
| 218542_at | CEP55 | Y | Y | Y | chromosome 10 open reading frame 3 | |||
| 218252_at | CKAP2 | Y | Y | cytoskeleton associated protein 2 | ||||
| 203764_at | DLG7 | Y | Y | discs, large homolog 7 (Drosophila) | ||||
| 203358_s_at | EZH2 | Y | Y | Y | enhancer of zeste homolog 2 (Drosophila) | |||
| 213911_s_at | H2AFZ | Y | Y | Y | H2A histone family, member Z | |||
| 202503_s_at | KIAA0101 | Y | Y | Y | Y | KIAA0101 | ||
| 204709_s_at | KIF23 | Y | Y | Y | kinesin family member 23 | |||
| 202107_s_at | MCM2 | Y | Y | Y | MCM2 minichromosome maintenance deficient 2, mitotin (S. cerevisiae) | |||
| 204825_at | MELK | Y | Y | maternal embryonic leucine zipper kinase | ||||
| 204641_at | NEK2 | Y | Y | Y | Y | NIMA (never in mitosis gene a)-related kinase 2 | ||
| 201577_at | NME1 | Y | Y | Y | Y | non-metastatic cells 1, protein (NM23A) expressed in | ||
| 218039_at | NUSAP1 | Y | Y | Y | nucleolar and spindle associated protein 1 | |||
| 219978_s_at | NUSAP1 | Y | Y | nucleolar and spindle associated protein 1 | ||||
| 222077_s_at | RACGAP1 | Y | Y | Y | Y | Y | Rac GTPase activating protein 1 | |
| 201890_at | RRM2 | Y | Y | Y | ribonucleotide reductase M2 polypeptide | |||
| 209773_s_at | RRM2 | Y | Y | Y | ribonucleotide reductase M2 polypeptide | |||
| 209218_at | SQLE | Y | Y | Y | Y | Y | squalene epoxidase | |
| 1554408_a_at | TK1 | Y | Y | Y | Y | thymidine kinase 1, soluble | ||
| 202338_at | TK1 | Y | Y | Y | Y | thymidine kinase 1, soluble | ||
| 201291_s_at | TOP2A | Y | Y | Y | Y | topoisomerase (DNA) II alpha 170kDa | ||
| 201292_at | TOP2A | Y | Y | Y | Y | topoisomerase (DNA) II alpha 170kDa | ||
| 204822_at | TTK | Y | Y | Y | TTK protein kinase | |||
| 204026_s_at | ZWINT | Y | Y | Y | Y | ZW10 interactor |
*
: “Y” symbol was used to indicate the association of each malignancy-risk gene with cancer relapse/progression (Chanrion et al or Ma et al), or metastasis (van ‘t Veer et al, Wang et al, or Huang et al).