Table 1.
GCV IC50 (μM) | Relative to HSVTK | Percentage of cell killing achieved with ∼5% cell transfection | |
---|---|---|---|
pUB | 50 | 1 | N.A |
pUB:MGMK | 65 | 0.77 | N.A |
pUB:HSVTK | 50 | 1 | N.D |
pUB:30 | 0.4 | 125 | 23% |
pUB:SR39 | 0.02 | 2,500 | 46% |
pUB:MGMK/HSVTK | 0.5 | 100 | 45% |
pUB:MGMK/30 | 0.004 | 12,500 | 72% |
pUB:MGMK/SR39 | 0.02 | 2,500 | 71% |
N.A = Not Available
N.D = Not Detected