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In vitro cytotoxicity and bystander response of rat C6 glioma cells expressing wild type, mutant HSVTKs, wild type fusion or mutant fusion constructs to GCV.
| GCV IC50 (μM) | Relative to HSVTK | Percentage of cell killing achieved with ∼5% cell transfection | |
|---|---|---|---|
| pUB | 50 | 1 | N.A |
| pUB:MGMK | 65 | 0.77 | N.A |
| pUB:HSVTK | 50 | 1 | N.D |
| pUB:30 | 0.4 | 125 | 23% |
| pUB:SR39 | 0.02 | 2,500 | 46% |
| pUB:MGMK/HSVTK | 0.5 | 100 | 45% |
| pUB:MGMK/30 | 0.004 | 12,500 | 72% |
| pUB:MGMK/SR39 | 0.02 | 2,500 | 71% |
N.A = Not Available
N.D = Not Detected
