Fig. 6.

Snap-shot from a coarse-grained molecular dynamics simulation of the action of an arylamide on the bilayer at an oligomer/lipid ratio of 1:256 (left) and 1:14 (right)⁹⁵. The backbone of the foldamer is shown in blue and yellow, while the headgroups of the membrane and polar groups of the foldamer are shown in purple and red. The lipid chains are shown as sticks. The right panel represents an intermediate time point at which foldamers have inserted deeply, and are beginning translocate across the bilayer.