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. Author manuscript; available in PMC: 2011 Jan 19.
Published in final edited form as: Acc Chem Res. 2010 Jan 19;43(1):30–39. doi: 10.1021/ar900036b

Table 1.

Conformational tuning of properties of antimicrobial oligomersa.

Compound Structure MIC (μM)
S.
aureusb 		E. Coli
D31		 HC50
(μM)c
2 graphic file with name nihms-151492-t0008.jpg 50 12.5 14
3 graphic file with name nihms-151492-t0009.jpg 7.8 3.9 445
4 graphic file with name nihms-151492-t0010.jpg 0.80 0.80 18
5 graphic file with name nihms-151492-t0011.jpg 0.87 0.87 145
6 graphic file with name nihms-151492-t0012.jpg 0.66 5.3 593
7 graphic file with name nihms-151492-t0013.jpg 0.70c 0.70 5
8 graphic file with name nihms-151492-t0014.jpg 0.2 2.8 63-90
9 graphic file with name nihms-151492-t0015.jpg 0.20 0.14 40
10 graphic file with name nihms-151492-t0016.jpg 0.20 0.10 440
a

Data were collected using the Hancock method; numbers quoted here may differ somewhat from those in the original publications if a different method was originally used to determine MIC’s.

b

Tetracycline and streptomycin-resistant S. aureus.

c

The concentration required to cause 50% lysis of a suspension of red blood cells.