Table 3.
Median plasma cytokine concentration in pg/ml (25th, 75th %ile)
| Cytokine | HbAA Controls | HbSS Controls | HbSS No Stroke | HbSS Stroke |
|---|---|---|---|---|
| L-1β | 16 (15, 18) | 19 (16, 22) | 19 (17, 23) | 17 (16, 18) |
| IL-1RA | 98 (77, 217) | 304 (243, 380) | 941 (260, 1491) | 287 (242, 477) |
| IL-4 | 3 (3, 4) | 6 (3, 6) | 3 (3, 4) | 3 (3, 4) |
| IL-5 | 12 (10, 13) | 22 (15, 22) | 13 (11, 13) | 13 (11, 14) |
| IL-6 | 9 (6, 10) | 10 (7, 16) | 11 (9, 13) | 10 (8, 14) |
| IL-7 | 29 (17, 40) | 44 (26, 56) | 25 (21, 29) | 22.50 (21, 27) |
| IL-8 | 9 (5, 14) | 15 (7, 27) | 12 (10, 29) | 16 (9, 19) |
| IL-10 | 11 (10, 13) | 16 (10, 19) | 12 (10, 16) | 11 (11, 13) |
| IL-12 | 14 (12, 18) | 20 (11, 28) | 14 (12, 19) | 11 (10, 15) |
| IL-13 | 16 (15, 21) | 20 (14, 25) | 15 (12, 21) | 10 (8, 17) |
| IL-17 | 40 (9, 65) | 96 (58, 139) | 6 (5, 19) | 32 (26, 44) |
| Eotaxin | 58 (49, 69) | 58 (38, 147) | 85 (64, 133) | 109 (81, 151) |
| G-CSF | 106 (78, 191) | 252 (97, 369) | 114 (95, 149) | 89 (86, 107) |
| GM-CSF | 43 (43, 43) | 82 (53, 110) | 173 (125, 221) | 10 (7, 77) |
| IFN-γ | 112 (99, 169) | 277 (124, 320) | 149 (115, 179) | 114 (99, 155) |
| IP-10 | 1171 (973, 1292) | 1279 (949, 2036) | 1248 (801, 1724) | 1166 (651, 1957) |
| MCP-1 | 26 (18, 42) | 17 (11, 28) | 33 (16, 116) | 27 (13, 41) |
| MIP-1α | 5 (4, 6) | 26 (12, 329) | 4 (4, 7) | 5 (4, 21) |
| MIP-1β | 96 (66, 150) | 245 (73, 325) | 254 (188, 393) | 205 (152, 367) |
| PDGF-bb | 4697 (2873, 71856) | 3876 (2194, 7100) | 8937 (6022, 13342) | 7960 (5024, 11932) |
| TNF-α | 57 (46, 70) | 124 (62, 148) | 57 (41, 65) | 58 (48, 73) |
| VEGF | 60 (19, 161) | 73 (35, 350) | 243 (78, 394) | 108 (52, 177) |
%ile, percentile