Skip to main content
. Author manuscript; available in PMC: 2011 Jan 1.
Published in final edited form as: Cytokine. 2009 Sep 22;49(1):1–9. doi: 10.1016/j.cyto.2009.08.010

Figure 2. PI3K pathway in TLR signaling.

Figure 2

PI3K physically interacts with multiple TLRs as well as MyD88. Activated PI3K regulates TLR signaling in both positive and negative ways. Inactivation of GSK3 by PI3K-Akt enhances the transcription of IL10 by allowing CREB DNA binding as well as CREB-CBP association. IL-12 transcription is inhibited due to decreased association of NF-kB with CBP. PI3K-Akt also phosphorylates mTOR which leads to the phosphorylation and activation of IRF-7 as well as enhanced production of type I IFNs. PI3K-Akt pathway is also involved in cell proliferation or survival induced by multiple TLR ligands through degradation of the cell cycle inhibitor p27.