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Simulations of mitochondrial (B) ΔΨ, (C) ATP/ADP, (D) ROS, (E) SEf1 + SEf2, (F) UCPa, and (G) UCPi time-dependent responses to (A) a plasma glucose profile from Breda et al. (31), under normal (solid curves) and inhibited (dashed and dash-dotted curves) UCP activation conditions. Dash-dotted curves show the combined effects of complete UCP activation inhibition with an increase of one-third in the mitochondrial density, p0. Intracellular calcium was held constant at 0.2 μM.
