Figure 1.
Leak and cotransport currents of wt hSGLT1 and C292A mutant. (A) The total currents of wt SGLT1 for five oocytes coming from three different donor frogs in normal saline solution, with 0.2 mM Pz or with 5 mM αMG. (B) The leak current was obtained by subtracting the current in the presence of 0.2 mM Pz from the current in normal saline solution. The cotransport current represents the increase in wt SGLT1 current on addition of 5 mM αMG. (C) The same solutions used in A were presented to the C292A mutant (n = 6). (D) The leak current and the cotransport current were extracted from the total currents (C) of the C292A mutant. Mean ± SE are shown.