Figure 4.

Effects of changing parameters in Model D on simulated current shape. (A–H) Each panel contains a simulated control current corresponding to a VC of −40 mV, and an analogous simulated current reflecting a change in one parameter. The parameters indicated were changed individually according to the average change induced by L-cys treatment in Model D when fitted to the six sets of control and L-cys records. (I) Effect of simultaneously making all the changes depicted in A–H. (J) Same simulations shown in I except the control simulation has been scaled at the peak to match the L-cys simulation.