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. 2010 Jan 20;98(2):197–206. doi: 10.1016/j.bpj.2009.10.007

Figure 5.

Figure 5

Simulations with Model F of recovery from inactivation. (A) Model F, with the averaged optimized rate constants corresponding to a voltage of −90 mV, obtained by fitting Model F to the six control records. (B) Same control current records as shown in Fig. 4 (thin black lines and corresponding simulation (thick lines) based on fitting Model F to the same records). (C) Recovery data simulated with Model F, superimposed on real recovery data acquired from five different T-rich DRG cells (2). Fitting the simulated data with a double exponential function indicated that 47 ± 8% of the current recovered with fast time constant (66 ± 4 ms), and 53 ± 8% recovered with a slower time constant (580 ± 112 ms). The same procedure applied to the real data indicated that 51 ± 8% of the T-current recovered with a fast time constant (105 ± 18 ms), whereas 49 ± 8% recovered with a slower time constant (981 ± 173 ms). The error bars represent the SE.