AFM height images of various biological samples contaminated by buffers crystals on fresh cleaved mica or clean glass cover. (a) Fibrous astrocyte, (b) K562 tumor cells, (c) Bovine cardiac mitochondria, (d) Escherichia Coli, (e) Indicus flight muscle fibers, (f) Rat tail collagen I fibers, (g) mtDNA strands, (h) Mitochondria F1-ATPase particles. Inset: improved height image of the concerned sample washed by DI-water (left), and local microstructure of concerned images polluted by buffers crystals (right).