Table 2.
SRS versus Surgery + WBRT
| First author (Year) | Interventions | Median survival | # pts with recurrence/progressiona | Median time to recurrence/progression |
|---|---|---|---|---|
| Randomized controlled trials | ||||
| Muacevic [23] (2008) |
G1: SRS (n = 31) G2: Surgery + WBRT (n = 33) |
G1: 10.3 months G2: 9.5 months (Log-rank; P = NS) |
1 yr local control rate: G1: 97% G2: 82% 1 yr distant recurrence rate: G1: 26% G2: 3% |
At original site: Median: NR (LR curves: log-rank; P = 0.06, NS) At distant brain sites: Median: NR (DR curves: log-rank; P = 0.04) |
| Retrospective cohort studies | ||||
| Muacevic [14] (1999) |
G1: SRS (n = 56) G2: Surgery + WBRT (n = 52) |
G1: 35 weeks G2: 68 weeks (Log-rank; P = NS) |
1 yr freedom from LR rate: G1: 83% G2: 75% 1 yr freedom from DR rate: G1: 68% G2: 90% (P = 0.0025) |
At original site: G1: Median not reached G2: Median not reached (Log-rank; P = NS) At distant brain sites: NR |
| Rades [15] (2007) | G1: SRS (n = 94) | Median survival: NR | 1 yr freedom from LR rate: | At original site: |
| G2: Surgery + WBRT (n = 112) |
1 yr survival rate: G1: 54% G2: 38% (Log-rank; P = NS) |
G1: 64% G2: 56% 1 yr freedom from BR rate: G1: 49% G2: 44% |
Median: NR (LR curves: log-rank; P = NS) Overall in brain: Median: NR (BR curves: log-rank; P = NS) |
|
BR Brain recurrence (local + distant), DR Distant recurrence in brain, G1 Group 1, G2 Group 2, LR Local recurrence at original site in brain, NR Not reported, NS Not significant, Pts Patients, SRS Stereotactic radiosurgery, WBRT Whole-brain radiation therapy
aNumber of pts with recurrence/progression of brain metastases, unless otherwise specified