Fig. 2.

SF1126 induces G1 arrest and inhibits proliferation. Cells were either untreated or treated with 40-μM SF1126 for 48 h, at which point they were fixed and stained with propidium iodide. DNA content was then analyzed by flow cytometry. Representative cell cycle profiles are shown for a SK-parental and SK-HRp2, and b BT-parental and BT-HRp3 cells. The percentages of c SK-parental and SK-HRp2cells, and d BT-parental and BT-HRp3 cells in G0/G1, S, or G2/M are shown. SF1126 induced cell cycle arrest at the G1 phase with reduced S phase (proliferating fraction) in all cells