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. 2009 Oct 19;587(Pt 24):5819–5830. doi: 10.1113/jphysiol.2009.180372

Figure 5. Expression of dnAMPK blocks the effects of sodium azide on TREK channels.

Figure 5

A, trace of wild-type TREK-1 conductance in the presence of dnAMPK and bath temperature show that heating from 24°C to 30°C increases TREK-1 activity. At 30°C bath application of sodium azide (10 μm) had no discernable effect on channel conductance. Inset, I–V plots of TREK-1 current in the presence of dnAMP obtained at 30°C during control conditions (a) and in the presence of azide (b). Bar graph of average data (n= 4) shows the percentage inhibition of TREK-1 by azide alone and in the presence of dnAMPK. B, trace of wild-type TREK-2 conductance in the presence of dnAMPK and bath temperature show that heating from 24°C to 30°C increases TREK-1 activity. At 30°C bath application of sodium azide (10 μm) had no discernable effect on channel conductance. Inset, I–V plots of TREK-2 current in the presence of dnAMP obtained at 30°C during control conditions (a) and in the presence of azide (b). Bar graph of average data (n= 3) shows the percentage inhibition of TREK-1 by azide alone and in the presence of dnAMPK.