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. 2009 Oct 19;587(Pt 24):5819–5830. doi: 10.1113/jphysiol.2009.180372

Figure 6. Sodium azide occludes AICAR-mediated inhibition of TREK channels.

Figure 6

A, traces of wild-type TREK-1 conductance and bath temperature show that heating from 24°C to 30°C increases TREK-1 conductance. At 30°C exposure to sodium azide (10 μm) inhibited TREK-1 conductance. In the continued presence of sodium azide, bath application of AICAR had no effect on TREK-1 conductance. Inset, I–V relationship of TREK-1 current obtained under control conditions at 30°C (a) and during exposure to azide alone (b) and azide in the presence of AICAR (c). Bar graph summarizes the percentage inhibition by azide alone and AICAR in the presence of azide. B, traces of wild-type TREK-2 conductance and bath temperature show that heating from 24°C to 30°C increases TREK-1 conductance. At 30°C exposure to sodium azide (10 μm) inhibited TREK-2 conductance. In the continued presence of sodium azide, bath application of AICAR had no effect on TREK-2 conductance. Inset, I–V relationship of TREK-2 current obtained under control conditions at 30°C (a) and during exposure to azide alone (b) and azide in the presence of AICAR (c). Bar graph summarizes the percentage inhibition by azide alone and AICAR in the presence of azide.