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. 2009 Oct 26;587(Pt 24):5843–5857. doi: 10.1113/jphysiol.2009.177162

Figure 1. Bidirectional long-term synaptic plasticity: dependence on membrane potential.

Figure 1

A, LTP or LTD were induced by applying the same stimulation protocol (100 impulses–100 Hz) from different holding potentials. B, sample traces have been taken during the induction protocol, demonstrating sustained firing at all induction frequencies. The plots show that the holding potential (Vh) before induction and the number of spikes elicited by the stimuli were similar at the different frequencies. The black circles represent experiments used for measuring the EPSCs (WC: whole-cell recording experiments; as in Fig. 2), the grey circles represent experiments used for calcium imaging (Img; as in Fig. 6), the white squares are obtained at 34°C. Data are reported as mean ±s.e.m.