Figure 4. Blocking pannexin 1 gap junction hemichannels reduces cell-to-cell communication in taste buds.

A, probenecid (1 mm), a blocker of pannexin 1 hemichannels, inhibits taste-evoked responses in presynaptic cells. B, summary of several experiments; P > 0.0001, n= 10, repeated measures ANOVA. C and D, probenecid treatment did not change taste-evoked responses in receptor cells (C), or in presynaptic cell responses evoked by KCl depolarization (D).