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Time course of the changes in urine output in CRF rats and sham-operated rats. Urine output was significantly increased after induction of 5/6 nephrectomy in CRF rats (both CRF-V (circle) and CRF-C (rectangle)), whereas there is no change in urine output after sham operation in control rats (triangle). *p<0.05 when CRF-V or CRF-C was compared with sham-operated control rats.
