Table 2.

Brain physiologic variables

Variable	Mean ± SE	Time to peak	Time to resolve (min)
Before spreading depression
pHo	7.30±0.01 (n = 33)
PtCO2, (Torr)	64±2 (n = 16)
${\left[{\mathrm{HCO}}_3^{-}\right]}_{\mathrm{o}}$ (mM)	30±/ (n = 16)
[NH3]o (μM)	2.3±0.1 (n = 17)
$\left[{\mathrm{NH}}_4^{+}\right]$o (μM)	116±11 (n = 17)
Peak during spreading depression
pHo
Alkaline	7.49±0.01 (n = 33)	—	—
Acid	6.93±0.02 (n = 33)	9±0.5 s	11.9±0.8
PtCO2 (Torr)	79±2 (n = 16)	37±2 s	6.6±1.3
${\left[{\mathrm{HCO}}_3^{-}\right]}_{\mathrm{o}}$ (mM)	14±1 (n = 16)	—	—
[NH3]o (μM)	4.4±0.3 (n = 17)	1.8±0.1 min	20.8±2.1
$\left[{\mathrm{NH}}_4^{+}\right]$o (μM)	382±30 (n = 17)	—	—

Note: Pt_CO2, brain tissue PCO₂; n number of spreading depressions.