Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Dose escalation schema
| Dose level | Dose (mg) | Dosing schedule (every 28 days per cycle) | |
|---|---|---|---|
| 1 | 5 | 28 days ON | Continuous |
| 2 | 10 | 28 days ON | Continuous |
| 3 | 20 | 28 days ON | Continuous |
| 4 | 15 | 21 days ON; 7 days OFF | Intermittent |
| 5 | 20 | 21 days ON; 7 days OFF | Intermittent |
| 6 | 25 | 21 days ON; 7 days OFF | Intermittent |
| 7 | 30 | 21 days ON; 7 days OFF | Intermittent |
| 8 | 35 | 21 days ON; 7 days OFF | Intermittent |
| 9 | 40 | 21 days ON; 7 days OFF | Intermittent |
