Table 4.
Treatment-related adverse events for intermittent dose (n=35)
| Adverse Events | Grade 1 | Grade 2 | Grade 3 | Grade 4 |
|---|---|---|---|---|
| Blood/Bone Marrow | ||||
| Anemia | 1 | 1 | 1 | |
| Leukopenia | 1 | 1 | ||
| Neutropenia | 1 | 2 | 2 | 3 |
| Hemolysis | 1 | 1 | ||
| Thrombocytopenia | 3 | 2 | ||
| Cardiovascular | ||||
| Supraventricular arrythmia | 1 | |||
| Edema | 4 | |||
| Constitutional symptoms | ||||
| Fatigue | 14 | |||
| Fever | 4 | |||
| Insomnia | 5 | |||
| Dermatology/skin | ||||
| Rash/desquamation | 7 | 3 | ||
| Pruritus | 4 | 1 | ||
| Gastrointestinal | ||||
| Anorexia | 3 | 1 | ||
| Constipation | 4 | 5 | ||
| Diarrhea | 5 | 1 | ||
| Dysgeusia | 3 | |||
| Nausea | 9 | 1 | ||
| Infection | 1 | 2 | ||
| Neurology | ||||
| Dizziness | 8 | |||
| Pain | ||||
| Myalgia | 5 | 1 | ||
| Pulmonary | ||||
| Pleural effusion | 2 | 1 |