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. 2009 Nov 11;38(Database issue):D670–D675. doi: 10.1093/nar/gkp957

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© The Author(s) 2009. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Duplicability, orthology and network properties of the tumor suppressor gene PTEN. (A) Using the PTEN protein sequence as a query, three hits are found on the human genome. The best hit corresponds to genomic locus of PTEN, while the two additional hits account for a recent duplication transcribing for the processed pseudogene PTENP1, and to a short region of identity lying in the intron of ANKFN1, respectively. (B) The orthology ratio reflects the co-orthology relationships of human PTEN at different branching points of the tree of life. The only inparalogs of PTEN in eukaryotes are found in A. thaliana and D. rerio, indicating that this gene maintained a strict singleton status during eukaryotic evolution. (C) PTEN interacts with 35 other human proteins, four of which are cancer proteins and 22 are hubs. This makes PTEN a central node of the human protein-protein interaction network.