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. 2009 Nov 6;38(Database issue):D552–D556. doi: 10.1093/nar/gkp937

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© The Author(s) 2009. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Interactions of prostaglandin-endoperoxide synthase 1 (PTGS1). (a) The highest-scoring interaction partners of PTGS1 are non-steroidal anti-inflammatory drugs (NSAIDs). As the confidence scores for these interactions are very high, no interacting proteins are shown. (b) The user may ask STITCH to display more of the interaction context and to let at least one-third of the interaction partners be proteins. In this case, STITCH is skipping 19 high-scoring chemicals in order to include four interacting proteins. In both networks, the color of the edge corresponds to the type of connected nodes (e.g. green: chemical–protein interaction) and the width of the edge correlates with the confidence score.