Table 1.

Statistics of the new TSS Seq data

Panel A
Sample name			Cell type		Condition	Time course	Tag count
DLD1 (Hypoxia with non-tagged RNAi)			Fibroblast		1% O2	24 h	7 723 359
DLD1 (Hypoxia with HIF1A RNAi)			Fibroblast		1% O2	24 h	7 727 105
DLD1 (Normoxia with HIF1A RNAi)			Fibroblast		21% O2	24 h	7 410 902
DLD1 (Hypoxia with HIF2A RNAi)			Fibroblast		1% O2	24 h	8 737 554
DLD1 (Normoxia with non-targetedRNAi)			Fibroblast		21% O2	24 h	8 644 835
DLD1 (Normoxia with HIF2A RNAi)			Fibroblast		21% O2	24 h	8 353 702
Beas2B overexpress STAT6 IL4+			Bcell		IL4	4 h	22 954 017
Beas2B overexpress STAT6 IL4−			Bcell				21 127 774
Beas2B parent IL4+			Bcell		IL4	4 h	15 166 848
Beas2B parent IL4−			Bcell				11 628 747
Beas2B stat6 siRNA− IL4+			Bcell		IL4	4 h	8 243 100
Beas2B stat6 siRNA− IL4−			Bcell				7 857 509
Beas2B stat6 siRNA+ IL4+			Bcell		IL4	4 h	5 879 777
Beas2B stat6 siRNA+ IL4−			Bcell				5 931 745
Ramos IL4+			Bcell		IL4	4 h	15 268 493
Ramos IL4−			Bcell				15 759 413
MCF7 O2 1%			Breast adenocarcinoma		1% O2	24 h	7 531 326
MCF7 O2 21%			Breast adenocarcinoma		21% O2	24 h	13 609 932
TIG O2 1%			Fetal lung		1% O2	24 h	8 848 737
TIG O2 21%			Fetal lung		21% O2	24 h	9 235 808
293 O2 1%			Embryonic kidney		1% O2	24 h	10 590 128
293 O2 21%			Embryonic kidney		21% O2	24 h	8 162 101
Fetal Heart			Normal fetal tissues				10 182 282
Fetal Kidney			Normal fetal tissues				8 424 482
Fetal Liver			Normal fetal tissues				4 741 889
Fetal Thymus			Normal fetal tissues				7 122 556
Fetal Brain			Normal fetal tissues				11 285 710
Brain			Normal adult tissues				11 561 960
Heart			Normal adult tissues				9 378 901
Kidney			Normal adult tissues				11 196 359
Mouse 3T3			Fibroblast				20 246 303
Total							330 533 354

Panel: B
	Average 5′-end clusters per cell	Average number of TSCs > 5ppm per cell		Number of represented genes (coverage against total RefSeq genes)
RefSeq region	105 134	6972		17879/18001 (99%)
Intergenic region	40 537	1083		ND