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. 2009 Nov 5;38(Database issue):D149–D154. doi: 10.1093/nar/gkp968

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© The Author(s) 2009. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Screenshot showing the interrelation of tools in HHMD. Users can start search by ‘Search’ menu or start directly from ‘HisModView’ menu. (A) Screenshot showing the starting points of the searching and visualization tools. HHMD offers five advanced search options, namely search by histone modification, search by gene ID, search by functional categories, search by chromosome location and by cancer name. (B) Screenshot showing the HisModView tool. Users can view histone modifications aligned by human genomic coordinates (hg18). Meanwhile, genomic annotations such as GC contents and RefSeq genes and MeDIP methylation data can also be visualized. Users can fine-tune the genomic regions by left/right shifting or zooming in/out. Users can hover on the the texts of histone modification types to gain further details. Users are allowed to download the histone modifications data of the present range. Users who are interested in genomic annotations can get details from pop-up menus. (C) Screenshot showing the ‘Search by histone modification result’ when specifying HM ID: HM-26. Users can either download the histone modifications data or visualize the data in HisModView.