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. 1998 Dec 22;95(26):15603–15607. doi: 10.1073/pnas.95.26.15603

Figure 2.

Figure 2

(A) Effect of IGF-I expression in EDL muscles of young adult (6 month) mice. Cross-sections stained with hematoxylin/eosin of control and AAV-injected EDL muscles from young adult mouse, 4 months post-AAV injection. AAV-injected EDLs (Upper Right) displayed significant increases in cross-sectional area compared with contralateral control EDLs (Upper Left). Muscle fiber regeneration was evident in injected EDLs (Lower Left) by the presence of central nuclei (arrow marks a central nucleus), which were absent in control sections (Lower Right). [Bars = 100 μm (Upper); 25 μm (Lower).] (B) Effect of IGF-I expression on muscle mass and force generation. The uninjected leg of each animal served as the control (defined as a value of 1) for the injected leg (expressed relative to the control value). Thus muscle mass (wet weight) and isometric tetanic force of AAV-injected muscles were expressed relative to the same measurements in the contralateral control muscle from the same animal. The average relative value (n = 5) for the injected limbs is plotted (±SEM). Asterisks denote a P < 0.05 for paired comparisons (Student’s t tests) between AAV-injected and control muscles.