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Maintenance of IIb fibers in muscle of old (27 month) mice by IGF-I expression. The loss of IIb fibers normally associated with aging was prevented by IGF-I expression in 27-month-old mice (n = 7). No effect on fiber type distribution by IGF-I expression was observed in muscles of 6-month-old mice (n = 5). Asterisks denote a P < 0.05 for comparisons (Student’s t tests) to young adult control muscles. Fiber types were determined as described by Schiaffino and Salviati (16).
