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. Author manuscript; available in PMC: 2010 Aug 1.
Published in final edited form as: Nat Immunol. 2009 Dec 27;11(2):155–161. doi: 10.1038/ni.1836

Fig 2.

Fig 2

The co-receptor CD36 is required for TLR4-TLR6-dependent responses. (a) Effect of CD36 and CD14 on oxLDL-induced expression of an NF-κB luciferase reporter gene in TLR4-TLR6 expressing HEK293 cells. (b-c) Chemokine gene expression analyzed by QRT-PCR in (b) wild type and Cd36−/− macrophages stimulated with oxLDL (50 μg/ml, 6h), and (c) aortas of Apoe−/− and Cd36−/−Apoe−/− mice (n=3) fed a high fat diet for 12 weeks to induce atherosclerotic lesion formation. (d) Reactive oxygen species production in wild type, Tlr4−/−, Tlr6−/− and Cd36−/− macrophages stimulated with oxLDL (50 μg/ml) or zymosan (1 μg/ml) for 45 min. Data are the mean ± s.d. of triplicate samples in a single experiment and are representative of an experimental n of 3. *p≤0.05.