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Tumorigenesis in Mdm2-transgenic mice. Twenty Mdm2-transgenic mice (diamond), 11 homozygous (2×) transgenic mice (circle), and 20 Mdm2-transgenic/p53-null mice (triangle) were assayed for tumor formation. The rates of tumorigenesis in these populations was compared with the rates of tumorigenesis in 42 p53-null mice (hatched square) and 30 wild-type mice (open square).
